Yes — store unopened Trulicity in the refrigerator (36°F–46°F (2°C–8°C) before use). Once you start a pen, it can stay at room temperature: Per product-specific instructions Per product-specific instructions
Storage & timing for Trulicity
Practical handling guidance. Always follow the dispensed label.
Before use
36°F–46°F (2°C–8°C) before use
At room temperature
Per product-specific instructions
After first use
Per product-specific instructions
When to inject
Per prescribing label
If you miss a dose
Refer to product label or contact prescriber
Does Trulicity need to be refrigerated?
Before you open it, yes — keep Trulicity refrigerated at 36°F–46°F (2°C–8°C) before use. Do not freeze it; a pen that has frozen should not be used even after thawing. After first use, most people can keep the pen at room temperature: Per product-specific instructions Track the date you first used it so you know when to discard: Per product-specific instructions
What if Trulicity was left out of the fridge?
An unopened pen left at room temperature is generally still usable within the room-temperature window on the label (per product-specific instructions), but once that window is exceeded — or if it was exposed to heat above the labeled limit or to freezing — it should not be used. If you are unsure how long it sat out or how warm it got, call your pharmacist before injecting; do not guess. Never use a pen that has been frozen.
Traveling with Trulicity
For trips, carry Trulicity in an insulated bag with a cold pack (not directly touching the pen, to avoid freezing) and keep it in your carry-on, never a checked bag or a hot car. At your destination, refrigerate any unopened pens. Airport security allows medically necessary medication and cold packs; a pharmacy label or prescription can smooth the screening.
When to take Trulicity
Per prescribing label If you miss a dose: Refer to product label or contact prescriber
Common questions
Does Trulicity need to be refrigerated?
Unopened Trulicity is kept in the refrigerator (36–46°F / 2–8°C). Its label then allows a defined stretch outside it: up to 14 days total at room temperature — the shortest allowance in the class. Never freeze an injectable pen; if it freezes, do not use it.
How long can Trulicity stay out of the fridge?
Up to 14 days total at room temperature — the shortest allowance in the class, per the Trulicity label (prefilled pen). Limits differ by drug — Trulicity allows 14 days, the tirzepatide single-dose pens 21, a Wegovy pen 28 out of the fridge, and an Ozempic pen 56 from first use — so do not carry a figure over from a previous medication. If you are unsure how long yours sat out, ask your pharmacist before using it.
Can I travel with Trulicity?
Yes. Carry Trulicity in an insulated bag with a cold pack (not touching the pen, to avoid freezing) in your carry-on — never a checked bag or a hot car. Refrigerate unopened pens at your destination. Airport security permits medically necessary medication and cold packs; keeping the pharmacy label or prescription handy helps at screening.
Is Trulicity still good if it was left out overnight?
Often yes, if it stayed within the labeled room-temperature window and didn't get too hot or freeze — but check the number of days your product allows at room temperature and how warm it got. When in doubt, call your pharmacist rather than guessing. Never use a pen that has frozen, even once.