Free tool
GLP-1 cost per pound lost calculator
Cheaper monthly cost ≠ cheaper per-pound. Calculator factors clinical-trial average weight-loss percentages into effective $/lb cost. Surprising results — compounded tirzepatide often wins both monthly AND per-pound.
The short answer
The medication with the lower monthly price is often the more expensive one per pound lost, because the two drugs do not take the same weight off. Take a 200lb starting weight and each drug's own trial: Wegovy lists at $1,350 a month and averaged 14.9% over 16 months — about 30 lb for $21,600, or $725 a pound. Zepbound lists lower, at $1,086 a month, and averaged 22.5% over 17 months — about 45 lb for $18,462, or $410 a pound. Same list-price ballpark, 1.8× the cost per pound. Compounded tirzepatide comes out near $132 a pound on the same arithmetic, with the regulatory trade-off that it is not an FDA-approved finished product. Trial averages, not a promise about you — the calculator below runs it on your own weight.
Cheapest per pound lost
Compounded tirzepatide — $132/lb
Estimated 15.9 lb lost over 6 months at $2,100 total.
| Drug | Est. loss | Total cost | $/lb |
|---|---|---|---|
| Compounded tirzepatideCompounded | 15.9 lb | $2,100 | $132 |
| Compounded semaglutideCompounded | 11.2 lb | $1,500 | $134 |
| Zepbound | 15.9 lb | $6,516 | $410 |
| Mounjaro | 15.0 lb | $6,414 | $428 |
| Wegovy | 11.2 lb | $8,100 | $725 |
| Ozempic | 6.0 lb | $5,808 | $968 |
| Saxenda | 7.5 lb | $8,094 | $1079 |
| Rybelsus | 4.5 lb | $5,808 | $1291 |
Estimates based on STEP-1 (semaglutide), SURMOUNT-1 (tirzepatide), STEP-2 (semaglutide T2D), and SCALE (liraglutide) trial-average outcomes. Individual results vary widely. Trial doses assumed; lower toses produce proportionally less weight loss. Compounded prices based on typical telehealth flat-rate offerings.
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- Sesame Care· from $208/moTop ratedTelehealth · online visit
- SkinnyRx· from $199/moCompounded not offered in AL, LA, MS — check before startingTelehealth · online visitCompounded · not FDA-approved
- Enhance MD· price shown after their intakeNo lab work to startRestricted in AL, AR, GA, HI, LA, MS, MO, ND, SC, TN, WV — check before startingTelehealth · online visitCompounded · not FDA-approved
- HealthRX· from $165/moLowest starting priceon the 12-month plan, $1,188 billed upfrontTelehealth · online visitCompounded · not FDA-approved